Dosage and Administration: Healing of Erosive Esophagitis: 20 mg or 40 mg once daily for 4 – 8 weeks, followed by a further 4 – 8 weeks if not fully healed. Maintenance of Healing of Erosive Esophagitis: 20 mg once daily. Symptomatic Treatment of GERD: 20 mg once daily for 4 weeks followed by a further 4 weeks if not fully healed. NSAID-Associated Gastric Ulcer: 20 mg or 40 mg once daily for up to 6 months. Helicobacter pylori Associated Ulcer: One MAXIMA® 20 capsules, Amoxicillin (Moxilin) 1 g & Clarithromycin (Claricin) 500 mg all twice daily for 10 days. Zollinger-Ellison Syndrome: 40 mg twice daily.
USE IN PREGNANCY & LACTATION
Pregnancy category ‘B’. Esomeprazole secreted in the breast milk, so a decision should be made whether to discontinue nursing or the drug, taking into account the importance of the drug to the mother.
Common side effects include nausea, vomiting, diarrhea, constipation, abdominal ain, flatulence and headache. In rare cases pruritus, urticaria, dizziness and dry mouth may appear.
Esomeprazole may interfere with the absorption of drugs where gastric pH is an important determinant of bioavailability such as Ketoconazole, Iron Salts, and Digoxin.