Voligel® gel Description:
Diclofenac Diethylamine is systemically absorbed through the skin; it inhibits the enzyme cyclooxygenase, thus reducing the formation of PGE2. Moreover, it also increases the uptake of Arachidonic acid into the cellullar pool. Oleum Lini contains predominantly Essential Fatty Acids i.e. µ Linolenic acid. On percutaneous absorbtion, µ- Linolenic acid gets converted to Elcosapentanoic acid (EPA). EPA is acted upon by cyclo-oxygahase enzyme to produce prostaglandin E3 which is a weak inflammatory agent. Presence of EPA prevents the action of cyclo-oxygenase on Archidonic acid which reduces its coversion to PGE2 (a highly inflammatory agent). Presence of PGE3 itself modulates the inflammatory response through a feedback mechanism. Menthol is a vasodiator. It dilates the blood vessels, produces a feeling of coolness and produces analgesia. Methyl salicylate is a known anti-inflammatory agent.
Indicated for the quick relief from pain, swelling and inflalmmation due to musculo-skeletal disorders such as sprains, Strains, tendinitis, bursitis, hands, neck & shoulder pain, sciatica, muscle stiffness, joint pain, back ache and lumbago.
Approximately one inch band of Cream should be applied to the affected site three to four times daily with rubbing till the film disappears.
Usually well tolerated. Extremely low frequency of hypersensitivity reactions.Contraindications:
Known hypersensitivity to any part of the preparation.
For external use only.
Avoid contact with the eyes. Stop use and ask a doctor if condition worsens or does not improve within 7 days. Keep out of the reach of children. If swallowed, get medical help or contact a poison control center right away.
Store in a cool and dry place, protected from light.Commercial PackBox containing 50 gm tube. Each 100 gm Gel contains Diclofenac Diethylamine BP 1.16 gm (eq. to Diclofenac Sodium 1 gm).